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Main functions

Circadian control

• Synchronizes the day-night rhythm of all body cells via the suprachiasmatic nuclei (SCN) in the hypothalamus.

• Regulates sleep architecture (REM/NREM), body temperature, hormone secretion, blood pressure, blood sugar.

Antioxidant & Cell Protection

• One of the most powerful antioxidants known: directly neutralizes free radicals (OH·, O₂⁻, NO·).

• Activates the body’s own protective systems such as SOD, glutathione peroxidase, and catalase.

•    Protects mitochondrial membranes, maintains ATP production.

•    Is even produced in the mitochondria themselves — intramitochondrial melatonin.

Epigenetic & anti-aging

• Regulates over 100 genes, including DNA repair enzymes (PARP), sirtuins, and p53.

• Slows telomere shortening.

• Modifies histone acetylation → protects cell integrity and reprograms aging cells.

•    There is a close synergy here with Epitalon, which restores melatonin rhythms at the DNA level.

Immunomodulation

•    Supports the activity of NK cells, T cells, and macrophages.

• Anti-inflammatory (inhibits COX-2, NF-κB, IL-6, TNF-α).

• Immune balancing in autoimmunity and infections.

Cardiovascular & Metabolism

• Vasodilating via NO signaling pathways.

• Protects endothelial cells and reduces oxidative LDL damage.

• Regulates glucose homeostasis, insulin sensitivity, and lipid profiles.

Oncoprotective
• Antiproliferative in certain tumors (breast, prostate, colon).
• Induces apoptosis of degenerated cells.
• Enhances the effectiveness and tolerability of chemotherapy/radiotherapy.

In short, The Bioregulator Company 5 mg Melatonin melt tablets deliver fast, clean, and effective sleep and longevity support—a pharmaceutical-level formulation trusted for neuroendocrine and regenerative optimization.