Epitalon and Endoluten are peptides which were originally developed based upon the action of epithalamin, a hormone produced by the pineal gland. This hormone was found to stimulate the production of telomerase, an enzyme which plays a role in maintaining telomere length. Telomeres are non-coding terminal regions of DNA strands which preserve the integrity of the strand. With each revision, telomeres are shortened until the DNA strand cannot be further replicated. This process is highly implicated in the ageing process. Elongating telomeres theoretically extend the lifespan of a copy of DNA and allows it to replicate more times than usual. This was the theory behind the development of Epitalon®, a synthetic version of epithalamin which also stimulates the production of telomerase. Indeed, this theory has been confirmed in vitro inhuman cell cultures.
Neutralisation of Harmful Free Radicals
The role of antioxidants in mitigating damage from free radicals.
Cytotoxicity secondary to free radical damage has been implicated in the ageing process. Administration of epithalon has also been shown to exert an antioxidant effect. The presence of toxic compounds within the body can lead to the formation of reactive oxygen species (ROS) which can damage DNA, leading to cellular death &/or mutations leading to the formation of cancerous cells. Maintaining the integrity of the genetic information stored in DNA is one of the mechanisms in which peptide bioregulators work to prevent cancer.
Attenuation of Inflammation
Inflammation is a normal immune response that can become dysregulated and potentiated in a broad spectrum of disorders from rheumatoid arthritis to ulcerative colitis and even has been implicated in psychiatric disorders. The inflammatory process is dependent upon intercellular communication mediated by biomolecules such as cytokines, C-reactive protein, and other acute phase reactants. Epithalamin has been observed to play a role in the regulation of these molecules & thus attenuate the inflammatory response.
Hormones are responsible for many key signalling circuits between cells which on a larger scale comprise the functions of large organs. For example, melatonin is a hormone which regulates the circadian rhythm, an internal biological clock. Endogenous melatonin production has been observed to decrease with ageing. A 2007 study of Epitalon administration in elderly patients found that the compound helped to restore pineal gland function & increased release of melatonin, which is purported to be the mechanism behind the restoration of sleep.
Gene expression is different in young, middle-aged, and old individuals. The body times the life cycle using gene expression. In childhood, genes dictate the body to grow, in the middle age they maintain the body strong and healthy, and in the old age they dictate the body to stop releasing vital hormones, thus slowing down life processes and destroying the body.
Telomerase (a.k.a. telomere terminal transferase) is the enzyme capable to elongating telomeres in human bodies while protecting the DNA from the damage caused by aging. When cells multiply, they are set a predefined number of cycles they can perform the divisions due to the permanent curtailment of telomeres. In Mr. Khavinson’s studies, Epitalon treated cells made a total of forty-four passages (ten extra divisions compared to normal cells). Thus, the studies support the evidence that Epitalon prolongues the life of cells due to overcoming of the Heyflick division limit. (Reference: V. Khavinson et all. in Bulletin of Experimental Biology and Medicine. June 2003, PMID: 12937682).
Excerpt from a recent article in the french scientific magazine “La Recherche” (The Research) of June 2014
Growing up in a poor and unstable environment alters the genome.
We know that stress contributes to accelerate a natural process in adults : the
Telomeres resemble the plastic tips on the ends of the shoelace that prevent it from fraying.
There are many theories of aging, one of which is the shortening of telomeres in our DNA. A telomere is like the plastic tip on the end of your shoe lace. It protects the DNA from unraveling during each cell division. Each cell division results in a slightly shorter telomere length, and eventually, the cell can no longer divide. This is called the Hayflick Limit, after Dr. Leonard Hayflick’s discovery that cells have a limited number of times that they can divide. In mammals, the telomeres are protected from shortening until the onset of sexual maturity. After that, they begin to shorten with each cell division, eventually leading to an inability to divide any more in order to replace worn out, damaged or diseased cells. There is an enzyme called telomerase that is produced in the cells which stimulates the lengthening of the telomeres. The pineal gland produces a hormone called epithalamin that tells the cells to produce telomerase which in turn results in longer telomeres in our DNA. The functionality of the pineal gland declines with age, and is partly responsible for age related diseases
FROM EXPERIMENT TO MEDICINAL SUBSTANCES
Long-term investigations performed by the research team of the Institute resulted in creating a new class of geroprotectors – peptide bio regulators. The administration of peptide bio regulators enables effective prevention of premature ageing and therapy of age-related diseases.
Researchers of the Institute are the inventors of a number of medicinal and prophylactic pharmaceutical substances, which are presently under serial production:
6 geroprotective medications (Thymalin, Thymogen, Epithalamin, Prostatilen, Cortexin, Retinalamin);
30 types of cell metabolism bio regulators,
5 highly efficient synthesized peptides (Vilon, Epitalon, Cortagen, Livagen, Prostamax), which largely have no analogues in other countries.
There were chemically synthesized over 100 biologically active peptides which revealed the ability to hold back the process of ageing.
According to the concept of peptide bio regulation, a theory of endogenous peptide bio regulators’ involvement in the maintenance of structural and functional homeostasis of cell populations, containing and producing these factors, was formulated. These endogenous peptides became commonly known as “Cytomedins”.
Cytomedins control gene expression and protein synthesis, thus preventing age-related accumulation of quantitative structural and functional alterations, which are the markers of transition of a biological system from the norm to the pathology. Disordered peptide bio regulation reduces organism resistance to external and internal destabilizing factors, serving a cause of premature ageing.
A long record of peptide bioregulators application in the health service has demonstrated their high effectiveness in combating various disease and pathologies, including those refractory to other medicines.
The researchers developed a new technology for creating biologically active food supplements (parapharmaceuticals), based on peptide complexes isolated from animal organs and tissues. A new group of parapharmaceuticals has received a name of “Cytomaxes”. Biologically active food supplements are produced in the form of tablets and capsules. Cytomaxes exert a regulatory effect on the cellular level and are used for improving the organism resistance to the impact of adverse environmental, climatic, occupational and other factors, as well as during the rehabilitation period after surgeries, traumas, diseases; in case of malnutrition, high physical loads; for the purpose of maintaining the functions of the main organism systems in old and very old persons in order to reduce the risk of disease occurrence.
Laboratory of the Swedish Government Authorisation / EEA Agreement
Analyses of the Bio Regulators
Results: Neither drugs doping drugs, medication or danger to health has been demonstrated (GC / MS)
Information: The products are a peptide complex containing amino acids
Opinion: The product is deemed to be a food supplement[/fusion_text]
Molecular-genetic test carried out in our clinic allows to reveal predisposition to the development of some diseases such as ischemic heart disease, arterial hypertension, thrombosis and thrombophilia, diabetes, Alzheimer’s disease, cirrhosis, chronic bronchitis, and a number of oncological and other diseases.
The knowledge of genetic predisposition to development of a particular disease allows to plan ways for its early prevention.
Welcome to Peptide-Bioregulator.com
Therapeutic peptides are a fast growing industry and many molecular therapies are being explored in the best companies and universities such as the Medical Institut in Saint Petersburg. This peptide mapping and synthesis research is providing interesting advances that allow biochemical focus on proteins, peptides and specific growth factors that are delivered to the target cell receptors . Through these signal transduction molecules can stimulate unwanted cell function. This biotechnology is already used in several countries as a protocol for the treatment of neurological and autoimmune disorders.
Our company consists of a team of enthusiastic and qualified employees, who always help our customers with professional advice.
We offer unique organic Bio Regualtors as well as Anti-Aging cosmetics with Amino Acid. If you have any questions, do not hesitate to contact us.
Peptide Bio Regulator Europe AB
European Medical Center for Peptide Bio Regulation
S-422 46 Göteborg / Hisings Backa