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Curawell – Revolutionizing Curcumin Absorption
The Future of Curcumin Supplementation
Curawell is a specially developed curcumin supplement by Dr. Matthias Kraft, MD. It utilizes a
globally unique lipo-lyophilization technology, which optimally protects the sensitive curcumin
molecules and dramatically enhances their absorption in the body.
Curcumin Bioavailability: Formulation Comparison
– Traditional Curcuma Extract: Very low bioavailability (approx. 2-3%)
– Liposomal Curcuma: Moderate bioavailability (approx. 10-20%)
– Curawell (Lipo-lyophilized): Very high bioavailability (approx. 85% of an infusion)
– Curcumin Infusion (Reference Standard): 100%
Curawell thus achieves nearly the same efficiency as a direct infusion – but through a simple oral
intake.
Curcumin Bioavailability: Formulation Comparison
– Traditional Curcuma Extract: Very low bioavailability (approx. 2-3%)
– Liposomal Curcuma: Moderate bioavailability (approx. 10-20%)
– Curawell (Lipo-lyophilized): Very high bioavailability (approx. 85% of an infusion)
– Curcumin Infusion (Reference Standard): 100%
Curawell thus achieves nearly the same efficiency as a direct infusion – but through a simple oral
intake.
Product Bioavailability Compared to Infusion
Traditional Curcuma Extract approx. 2%
Liposomal Curcuma approx. 10-20%
Curawell (Lipo-lyophilized) approx. 85%
Why Curawell is Superior:
– Maximum absorption: 85% of infusion bioavailability – without invasive methods.
– Natural technology: No emulsifiers, solvents, or artificial additives.
– Highest stability: Freeze-drying combined with lipid protection preserves bioactive properties.
– Best tolerability: Especially gentle on the stomach and metabolism.
– Enhanced antioxidant effects: Effectively protects cells from oxidative stress.
– Longer shelf life: Optimal preservation of bioactive curcuminoids without quality loss.
Curawell enables the full potential of curcumin to be utilized for the first time in oral form –
safe, effective, and scientifically confirmed.
Source of analysis: PLENUM Dr. Born, Ennepetal.
The Bioregulator Company B.V.
Herengracht 449A
1017 BR Amsterdam
Netherlands
Website: www.peptide-bioregulator.com
Curcumin in Therapeutic Application: From Signal Pathway Modulation to Clinical Evidence
A professional conversation between Thorsten Schmitt and Dr. med. Matthias Kraft
Thorsten Schmitt: Matthias, Curcumin is often referred to as a "miracle cure," but for therapists, hard scientific facts are what truly count. Looking at the research landscape: What makes Curcumin such an extraordinary tool in integrative medicine?
Dr. med. Matthias Kraft: Curcumin is the prime example of a "multi-target" agent. Unlike many pharmaceuticals that often target only one specific receptor, Curcumin simultaneously intervenes in up to ten different signal transduction cascades. It alters biological milieus and influences cellular communication at levels that are decisive for chronic inflammation and neoplastic processes.
Thorsten Schmitt: Let’s focus on specific indications. Where are the study-based effects most clearly proven today?
Dr. med. Matthias Kraft: I primarily see five central areas supported by strong evidence:
1. Complementary Oncology: Curcumin inhibits central cancer drivers such as mTOR, STAT3, and NF-κB. Particularly significant is the suppression of the epithelial-mesenchymal transition (EMT). Studies show that Curcumin reduces the ability of tumor cells to transition into a migratory state, which can lower the metastasis rate. Furthermore, it can enhance the efficacy of chemotherapies and break down resistances.
2. Metabolic Syndrome and Type 2 Diabetes: Clinical studies prove that the administration of Curcumin can significantly lower glycosylated hemoglobin (HbA1c), fasting blood sugar, and triglyceride levels. An exciting mechanism here is the inhibition of aldose reductase, which prevents the formation of sorbitol in the CNS—a key factor in protecting against cerebral angiopathies.
3. Neuroprotection: Curcumin acts as a potent antioxidant in the brain, which is particularly susceptible to oxidative stress due to its high oxygen consumption. It has been proven to prevent the aggregation of Amyloid-β and protect neurons from toxic influences, playing a key role in the prophylaxis of Alzheimer’s and Parkinson’s.
4. Chronic Inflammatory Joint Diseases: In cases of osteoarthritis, studies have shown that Curcumin reduces inflammatory markers such as IL-1β and TNF-α. This leads to a measurable improvement in joint function and can reduce the need for classic NSAIDs, which in turn protects the stomach lining and the microbiome.
5. Biological Dentistry: Curcumin suppresses the growth of pathogenic germs like Porphyromonas gingivalis. Additionally, there is evidence that it promotes osteoblast activity and inhibits bone-degrading osteoclasts, which is essential for the stability of the periodontium and the integration of implants.
Thorsten Schmitt: In practice, we often hear that patients take Curcumin capsules but feel no improvement. Why is there frequently a gap between laboratory results and practical experience?
Dr. med. Matthias Kraft: This is due to the so-called "black box" of absorption. Curcumin is extremely poorly water-soluble and, when swallowed as a capsule, undergoes a massive first-pass effect in the liver. Often, less than 10% reaches the bloodstream. To clinically reproduce the aforementioned study results, we must utilize delivery forms that bypass the gastrointestinal tract.
Thorsten Schmitt: Are you referring to absorption through the oral mucosa?
Dr. med. Matthias Kraft: Exactly. Innovative melt-away lozenges allow the active ingredient to be absorbed directly into the venous bloodstream via the oral mucosa. Pilot studies have shown that we can achieve serum concentrations corresponding to up to 85% of an intravenous administration. For the therapist, this offers an exciting option within a combination therapy: we can set a therapeutic peak through a high-dose intravenous administration and subsequently use the melt-away lozenges as an ideal supplement to keep the active levels in the blood stable until the next infusion.
Thorsten Schmitt: Matthias, thank you very much for this well-founded overview of the clinical possibilities of Curcumin!
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