What is a Telomere?

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Telomeres and aging, how to act?

Scientists agree, telomeres are needed against aging, then the question is how to keep them?

Here is some information that will be useful to understand the problem and the solutions!

A telomere is a chromosome’s tail end or a repetitive DNA at the end of a chromosome which is highly related to a typical DNA sequence that undergoes replication in a distinctive manner. A telomere neutralizes a chromosome’s predisposition to shorten with every sequence of replication. In other words, telomeres act in a way to protects the end of our chromosomes from deterioration/aging.

The first account of this biological phenomenon was reported by Alexei Olovnikov in 1971 who later went on to win a Nobel Prize. Olovnikov was the first to suggest that DNA sequencing is lost in every single replicative phase until it reaches a critical level when cell division would stop. During the process of cell differentiation and cell division, certain enzymes duplicate our chromosomes so the DNA cannot continue regular duplication to the very end of a chromosome.

It is now believed that immortal strands of DNA avoid telomere loss. Scientists therefore believe that telomeres are essential for the stability of chromosomes and that the act of aging itself hinges on the replicative senescence hypothesis.

At the end of a chromosome, there’s a protective tip called a telomere that wears away over time; understanding that is the key to understanding aging.

It is clear that diet plays an important role, but also the stress and toxins found in our physical environment, air pollution, water, magnetic fields, etc. …

But even if we could get a perfect environment and nutrition, protecting us against 100% of the factors destroying our DNA or preventing them from proper expression and self-repair, we would still be limited by a key biological factor, limiting the number of possible reproduction for each of our cells.
This is what scientists call the Hayflick limit. The Hayflick limit was discovered by Leonard Hayflick in 1965. Hayflick observed that our cells divide 50 times maximum before dying. When cells approach this limit, they show signs of senescence. [fusion_builder_container hundred_percent=”yes” overflow=”visible”][fusion_builder_row][fusion_builder_column type=”1_1″ background_position=”left top” background_color=”” border_size=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none”][1]

We can limit the premature destruction of our telomeres but we can not extend them at will. Or rather we could not, because since the discovery of this limit due to our telomeres, many researchers have invested their time to find a solution.
They made the assumption that there must be a way to stimulate the production of long telomeres in cells, to overcome this deadly biological limit.

What are the ways to lengthen our telomeres?
Many products are sold as telomerase activators, expected to generate repair telomeres, but very few really work and have been proven in multiple independent studies.

Thousands of products and substances have been tested worldwide and in recent decades, and both products have met these conditions over multiple laboratory and in humans in real life conditions.
This is Epitalon and Endoluten, currently the only substances scientifically proven to can lengthen telomeres in human cells.

Epitalon and Endoluten are known for more than 20 years.

These are the only supplement in the world that contains both potent telomerase activators recognized by the scientific world as to lengthen human telomeres.

Moderate physical activity and minimal stress are also demonstrated as protecting our telomeres, and a healthy diet too.

Are there a lot of telomerase activators?
Unfortunately there are no other products discovered for which there is abundant scientific evidence of their positive activity on telomeres.

For example ask these vendors and manufacturers of products such as TA-65 or astragaloside IV to provide even only one published scientific evidence, and you find that they do not.
They sell you the wind of hope, but nothing works. To the contrary you can read yourself dozens of scientific studies published internationally on Epitalon or Endoluten …

Base your purchases on the science that proves the effect of the product and provide you with a qualified manufacturer that offers the best possible quality, and so you will make a good buy.

The choice is simple, who wants to extend his/her life and enable her/his cells reproduce continuously and without defects, take Epitalon or Endoluten … or both!

In addition, Epitalon does not just extend our telomeres, it also regulates many functions in our body, such as hormonal and immune functions. Many people feel very fast improvements in many areas.
Many studies also confirm the incredible effects of Epitalon on various health issues.

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For the first time in the world restoration and treatment of retinal functions

For the first time in the world medical and ophthalmological practice an unprecedented technology for restoration and treatment of retinal functions in case of different pathologies (including macular degeneration, retinitis pigmentosa, diabetic retinopathy, thermal injuries, etc.) has been discovered by the Medical Center in St.Petersburg

http://eng.gerontology.ru/medcenter/ophthalmology/

The technology is based on peptide bioregulators, isolated from animal organs and tissues, such as retina, vessels, brain, thymus, epiphysis or their synthesized analogues. In case of introduction into the organism, peptides become inductors of synthesis of the specific proteins, capable of restoring tissues, damaged by a disease or with ageing.

The efficiency of the conducted treatment course was evaluated according to the indices of visual acuity, electrophysiological test, eyeball image and subjective state of each patient. Improved visual functions were registered in 95% of the patients, which is absolutely unique. Nowadays in the world of medicine there are no methods of treatment for retinal diseases whose efficiency is comparable to that of the treatment with peptide bioregulators.
At our Medical Centre you can undergo the full course of the necessary ophthalmological examinations:  
Consultation and complex examination
Eidoptometry with correction
Field of vision analysis
Glaucoma detection
Fundoscopy with photorecording
Diagnostics of functional status of the lacrimal apparatus and lacrimal passages
Electrophysiological examination of retina

PRIORITY AREA OF CLINICAL ADMINISTRATION OF THE PEPTIDE BIOREGULATORS IN OPHTHALMOLOGY:
Macular degeneration: dry and wet forms
Recurrent post traumatic and post-inflammatory retinal degenerations
Retinitis pigmentosa
Complex myopia
Diabetic retinopathy
Tapetoretinal eye degeneration

Treatment of Retinitis Pigmentosa with peptide bioregulators.

For more information about the treatment and cost´s send as an email (medical.center@peptide-bioregulator.com) or give us a call (+46 760 655 769)

Unique method for restoration of retinal functions in case of different diseases

This publication is dedicated to the application of a complex of peptide bioregulators being highly effective in treatment of different retinal diseases (diabetic retinopathy, pigment retinitis, age-related macular degeneration etc.). It contains data on clinical observations, supported by the results of retinal electrophysiological tests and computer perimetry results.

This publication will be of interest to ophthalmologists and practitioners of medicine in different fields.

Relevance of the problem
Maintenance and restoration of functions of the eye, being one of the main sense organs, is among vital issues of modern medicine. 80% of information about environment people get by visual perception. Most of the professional and everyday activities have to do with visual functions, their slackening or loss has the utmost negative effect on the quality of life.

In the structure of the eye retina (nervous tunic of the eyeball) is one of the thinnest layers, being the most complex and highly differentiated tissue. Its complex structure makes it sensitive to light, allowing to perceive color and images and to convert them into a signal being sent straight to the brain. Position of the retina behind other optic structures, direct ingress of sun rays, peculiarities of the blood supply make it vulnerable to both external (sun rays, light striking, radiation) and internal factors. Retina is as a rule damaged in case of the following diseases: hypertension, diabetes mellitus, renal insufficiency etc. Smoking and alcohol consumption also negatively affect retina. It should be noted that any damage of the retina can lead to the impaired vision or even to complete blindness.

Among the most frequent retinal diseases there are age-related macular degeneration, hereditary retinal degenerations (including retinitis pigmentosa), complicated myopia, diabetic retinopathy. Modern methods of treatment based on the application of the known pharmaceutical substances do not lead to significant results. Usually a prognosis for a disease in these patients is unfavorable (gradual and progressive decrease in the visual functions up to blindness).

The authors developed a unique method for isolation from animal organs and tissues of peptides, having direct tissue specific effect. These preparations are complexes of peptides weighing up to 10 KDa. Modern technologies applied in the process of isolation of these peptides preclude any presence of viruses or prions.

In case of introduction into the organism, peptides become induktors of synthesis of the specific proteins, capable of restoring tissues, damaged by a disease or with ageing.

Experimental and clinical studies revealed its high efficiency in the treatment and restoration of retinal functions if compared to the known methods. In case of its administration, there were registered a several-fold increase in the rate of the retinal defect closure and restoration of the nervous receptor apparatus, as well as a decreased depression of its functional state (according to the results of the ERG test). Studies have been conducted both on animals with modeled innate retinal degeneration, and on those with induced lesions (including laser ones). In the clinical 2 practice this preparation turned out to be highly effective in the treatment of the aftereffects of retinal veins thrombosis, glaucoma, haemorrhagic retinopathies, retinal sun and laser burns and many other diseases.

At the same time there were also conducted clinical trials of other peptides, isolated from the pineal gland, thymus, cortex, vessels and other organs. Positive results of the clinical studies allowed to introduce these preparations into the Russian Pharmacopoeia.

A complex of peptides isolated from the pineal gland called Endoluten, turned out to be highly effective in case of complex treatment of diabetic retinopathy. This preparation also revealed pronounced antioxidant effect and especially pronounced geroprotective effect, contributing to the improvement of the cortex functions and reducing stress level.

A complex of peptides isolated from the cortex called Cerluten also turned to be highly effective in case of complex treatment of all retinal diseases. Cortexin exerts tissue specific effect on the cortex, contributes to the restoration of cerebral cortex neurons, improves processes of nervous management and adaptation of the organism to variable environmental conditions, activates cerebral cortex, exerts antioxidant and antitoxic effects. The preparation improves processes of memorizing, stimulates DNA reparation in the cortex and accelerates brain functions restoration after stress impact and ischemia. These effects are especially relevant for retina being a nervous tissue.

A complex of peptides isolated from the calves thymus called Thyreogen significantly enhances immune system activity and is effective in complex treatment of retinal diseases. This preparation stimulates tissue regeneration and hemapoiesis, suppresses tumour growth, reduces treatment period of chronic diseases.

A complex of peptides isolated from the vessels called Ventfort, significantly enhances rigidity of the vascular wall, and considerably contributed to the effective treatment of retinal diseases. Its application caused reduction in the vascular wall permeability, reduction in the haemorrhages size and acceleration of their resolution, reduction of neovascularisation.

The efficiency of the complex application of these peptide preparations in case of different retinal pathology was considerably higher if compared to the separate application.

A set of peptides for the treatment course is designed taking 3 into consideration specificity of the eye ball structure, and depending on the allocation and type of the damage as well as on the general state of the patient it includes peptides of the retina, thymus, pineal gland, cortex, vessels and other. It turned out that peptide bioregulators are most effective in case of age-related macular degeneration, retinitis pigmentosa, complicated myopia, diabetic retinopathy.

In recent years the Institute of Bioregulation and Gerontology has synthesized and studied a new group of peptide bioregulators being analogues of the complex peptide preparations. The activity of these preparations is higher than that of the earlier designed. These synthetic peptides are utterly promising for the application in practical medicine. These are short peptides (2-4 amino acids) of the retina, pineal gland, cortex, thymus, vessels etc. Also, a preparation which inhibits angiogenesis, has been synthesized, being very important especially for the diabetic retinopathy pathogenesis and lesion of the organs and tissues associated with diabetes in general. These peptides (Normoftal, Pancragen, Vesugen, Crystagen, Pinealon etc.) are widely used in the medical practice as the means for prevention and treatment of different eye diseases.

 We manage not only to stop the development of the pathologic process but in many cases also to restore lost functions. Peptide bioregulators are effective in the treatment of both wet and dry macular degenerations. We’ve designed tableted form of the preparations (biologically active supplements) which effect is comparable to the effect of those for injections. Application of these tableted preparations allows to extend effect of the injection preparations or even to substitute them. The effect is preserved in case of long-term treatment. Regular application of peptide bioregulators allows to enhance the achieved results while other preparations being applied in conservative treatment of this pathology (including such wide-spread preparations as Lucentis and Avastin) require intraocular administration.

We can definitely assert that nowadays in the world of medicine, there are no methods of treatment for retinal diseases whose efficiency is comparable to that of the treatment with peptide bioregulators.

Application of peptide bioregulators in case of diabetic retinopathy
According to different sources the world number of patients suffering from diabetes mellitus accounts for 230-245 million people [fusion_builder_container hundred_percent=”yes” overflow=”visible”][fusion_builder_row][fusion_builder_column type=”1_1″ background_position=”left top” background_color=”” border_size=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none”][2,4,5,18]. In the developing countries up to 6% of the population suffer from this disease while in the countries of the Latin America these patients account for almost 15% of the population [13,14,18,20]. In Russia there are registered about 3 million people with diabetes mellitus including 260 thousand of those insulin dependent. Meanwhile according to the epidemiologic studies the number of people with diabetes accounts for 8 million people [1,4,9]. One of the most severe complications of the diabetes mellitus is a diabetic retinopathy, which is a progressive lesion of the retina, requiring laser and surgical intervention. Retinopathy develops in 97% of patients suffering from the diabetes mellitus type 1 for 20 and more years, and in 80-95% of the patients suffering from diabetes mellitus type 2 [5,6].

Peptide bioregulators enhance activity of the blood antioxidative system, including enzymes of the antioxidative defence, due to neutralization of highly toxic hydroxyl and peroxyl radicals, generated in the process of free radicals oxidation, this being very important in case of diabetes. They contribute to restoration of the damaged structures of the vascular wall and intercellular contacts restoration, affecting processes of the intracellular regulation. As a consequence they resolve haemorrhages and plasmorrhages, lessen edemata, regenerate and enhance cellular living potential.

In several cases in patients, who suffer from a very severe form of this disease associated with a severe proliferative process, after several courses of peptide bioregultors it became possible to conduct surgical treatment, which before had been denied to these patients due to its hopelessness.

Further on we give an example of one of our clinical observations.

Clinical observation No 1.
Patient M.E.E., born in 1972.

Diagnosis: diabetes mellitus type 2, proliferative diabetic retinopathy, pseudophakia, right eye subatrophy, condition after the vitrectomy in the left eye.

The patient had been being observed at the Medical Centre Institute of Bioregulation and Gerontology from 1999 till 2005. She underwent 11 courses (10 days each) with a complex of bioregulators. Visual acuity upon admission – 0.4-0.5, on discharge – 0.85. During the period of observation there were registered a significant widening of the field of vision in the sole seeing eye and considerably improved ERG indices. 4

Results of the visual functions tests before and after the treatment course
Field of vision test (computer based perimetry, ‘Pericom’)

Peptides application in case of retinitis pigmentosa (RP)

Retinitis pigmentosa is one of the most severe and frequent hereditary retinal diseases [15,26]. Its prevalence in the world on the average accounts for one patient per 5000 people [10,11]. S.F. Shershevskaya [11] reported 0.01% cases of retinitis pigmentosa in unselected population. The rate of carriage is 2% [8].

At the Medical centre of the Institute we’d treated patients from different countries who failed to get any help in any other medical institutions and came to us after several years of desperate attempts to improve or stabilize their vision functions.

We should emphasize that right after the first treatment course they reported increased visual acuity, significant widening of the fields of vision, improved scotopic (twilight) vision. With every reason we may say that there are no examples of such positive results observed after the treatment of this pathology in the world. In case a patient regularly undergoes courses of peptide bioregulators we reveal no negative dynamics of this severe pathology at all.

Peptides application in case of age-related macular degeneration
In the developed countries of the world as well as in the USA age-related macular degeneration is a leading cause of the blindness in patients aged 50+ [12,14,16,17,19,21,25,30].

According to the official data of the Centre of the World Health Organization on Prevention of the Recoverable Blindness its frequency accounts for 300 cases per 100 thousand of population, and in the world in general there are 25-30 million people suffering from this disease [3]. R. Klein et al. [22,23], B. Klein [24] show that first symptoms of this disease are registered in 40% of people aged 40+, and in more then 60% of people aged 60+ according to R.A. Williams et al. [29].

The World Health Organization reports that by 2025 this disease will be registered in 25% of the total world population. Age-related macular degeneration morbidity rate in the last decades reveals epidemic trends. 7

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To rejuvenate is prohibited by your government!

There is a product scientifically proven to rejuvenate the biological clock of humans and mammals, yet no public information is available.
Scientists around the world have shown that Epitalon & Endoluten stimulated the production of telomerase in cells, allowing to extend the ends of our chromosomes, allowing our healthy cells to reproduce again and again, beyond the limit they had reached.

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Rejuvenated cells will live longer, and by taking regularly Epitalon or Endoluten, you can extend their life endlessly, and thus remain healthy over the years that accumulate.

The discovery of anti- aging Epitalon & Endoluten date more than 20 years, [/fusion_builder_column][fusion_builder_column type=”1_1″ background_position=”left top” background_color=”” border_size=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none”][1] and despite thousands of people (most of whom are doctors or scientists) can testify to its beneficial and rejuvenating effects, Epitalon is available on the internet since 2013, when we decided to end the concealment orchestrated by those in power, having the right to choose our destiny.
More than 100 studies have been published in English on Epitalon [2]. Even more if we add other languages, including Russian, where Epitalon is studied since the 1970s [3].

Epitalon contributed to a significant increase in the duration of animal life in many experiments [5, 6, 7, 8, 9, 10].

Several other peptides show incredible health effects (BP157, Vilon, Cortagen, Livagen, GHK-Cu, …),and are the most successful products ever discovered to heal the body, repair it, rebuild it. Peptides are not fighting against pathogens, but they restore the performance of the organs for which they operate.
Epitalon is proven for strengthening and repairing the nervous system and the immune system, so why only specialists know about it and need to prescribe it unofficially ?

Epitalon is the only scientifically proven way to rejuvenate human cells, thus it should be known to all !
Of course there is some good information given to the public from time to time, when a spectacular scientific study proves that it is possible to reverse aging, but they never talk about the products that are already available !

Here for example the story on ABC channel, talking about the mice rejuvenated by Dr. Pihno, but as you can see they had less than 25,000 visitors, proving that the general public is kept uninformed, and believes that aging is a mandatory thing …

Study Suggests Scientists Reversed Age-Related Diseases in Mice

 

Scientists have turned back the clock in mice they engineered to age faster than normal, an advance they suggest is the first time aging in mice has been reversed.

Scientists have turned back the clock in mice they engineered to age faster than normal, an advance they suggest is the first time aging in mice has been reversed.

Researchers at Harvard-affiliated medical centers genetically manipulated mice to age faster, and then used gene therapy to lengthen telomeres — compounds found at the ends of strands of DNA — which reversed age-related problems such as decreased brain function and infertility.

“We at best expected it to be a slowing of the process or perhaps an arresting of the process. We did not anticipate that it would be so dramatic a reversal in all of the problems that the animal was experiencing,” said Dr. Ronald DiPinho, professor of medicine and genetics at Dana-Farber Cancer Institute and Harvard Medical School, and co-author of the paper published Sunday in the journal Nature. “We were so struck by the findings that we rushed to get the study published.”

A human cell holds 23 pairs of chromosomes, each containing protective caps at each end called telomeres. Enzymes called telomerases protect the telomeres and reduce DNA damage thought to contribute to tissue aging. But as we age, our cells produce less telomerase; telomeres are cut shorter and eventually fail to protect DNA from damage.

Researchers boosted telomerase in the mice cells — which hold 20 pairs of chromosomes — to prevent telomeres from getting shorter. They found restoring the enzyme not only stopped aging but revived failing organs and even restored dark fur to mice who had turned grey. DePinho said the mice that were equivalent to ages 80 to 90 in human years returned to the equivalent of middle age.

“This research indicates there’s a point of return for these tissues,” said DePinho. “The fact that you can bring a tissue to the brink and then bring it back this dramatically is remarkable.”
Previous studies suggest that even in humans, shorter telomeres may be associated with age-related diseases such as heart disease and Alzheimer’s disease.

In fact, the brains of the age-modified mice were 75 percent of the size of a normal brain, much as happens in a patient with Alzheimer’s disease. But when researchers reactivated the telomerase, the brains returned to a normal size, according to the study.

The aging process is complex and telomeres are just one element that contributes to its course. But DePinho said this is one step in learning more about not only the slowing of aging, but also the reversal.

“Telomere dynamics in mice has taught us the role of telomeres in [diseases like] cancer and helped us better understand how to take advantage of these situations,” said DePinho.

Here we know all these scientific studies, thus we know it is possible to live much longer and in good shape, and our Epitalon is the first evidence that we put at your disposal.
The results are surprising and witnesses of these rejuvenations are often speechless in front of our users of Epitalon who look years younger in just a few weeks.
Indeed Epitalon rejuvenates the cells, and effects therefore are found inside but also outside of the body. Some users are reporting us a tightening of their skin and refining of the poresremoving them 10 years of age after just a few weeks of taking it !

So spread the word, ”Aging is not a fatality , it can be reversed!“

References:

[1] Regulating Ageing with peptides. Insitute of Gerontologie of St Petersburg. Online here
[3] Experimental research on ageing in Russia. Online here[/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]