Epitalon 1 ml Ampules AE-0 100 mcg/ 5 ampules

Khavinson Peptides


Regulation of protein synthesis using Khavinson peptides

Adding peptides to cellular cultures resulted in a tissue-specific stimulation of protein synthesis in the cells of the specific organ, from which these peptides were obtained. This effect of enhancing protein synthesis was diagnosed in young and old animals. It was proven that small peptides exert tissue-specific stimulation on expression of differentiation factors CXCL12, Hoxa3, WEGC1: peptide KEDW – in cells of the pancreas, peptide ADEL – in the bronchial epithelium [66] and peptide AEDG – in fibroblasts. At the same time an induction effect from the peptides on the expression of differentiation factors is most pronounced in the ‘old’ cell cultures. This established their geroprotective mechanism. Moreover, the KEDW peptide increases expression of metalloproteinases (MMP2, MMP9), serotonin, glycoprotein CD79α, antiapoptotic protein Mcl-1, proliferation factors PCNA and Ki67 and also reduces expression of proapoptotic protein p53 in the ‘old’ cultures of the pancreas cells. Peptide AEDL regulates synthesis of proteins Ki67, Mcl-1, p53, CD79, NOS-3 in cultures of human bronchial epithelial cells of different passages. This contributes to activation of cell renewal and enhances functional activity of bronchial epithelium cells.

In the cell cultures of human cortical thymocytes, KED peptide enhanced differentiation of thymocytes towards regulatory T-cells, increased their proliferative activity and reduced apoptosis. Moreover, peptide KED stimulated proliferative (Ki67) and anti-apoptotic (Mcl-1) activity of mature regulatory T-cells. In the studies conducted the peptide KED effect on bone marrow stem cells CD34+, was shown to stimulate expression markers of myeloid cells CD14 and B-lymphocytes CD19.

KED stimulating impact on proliferation and its inhibitory effect on apoptosis was multifold in the pineal organotypic cell culture of old rats as compared to that obtained from young animals. This fact evidences the ability of the tripeptide under study to produce a pronounced restorative effect on the cells of the pineal gland within its ageing associated involution. Moreover, the model of maintaining conditioned responses in short-term and long-term memory of melliferous bee helped to reveal KED modulating activity on associative training .

EDR peptide in organotypic cultures of the old rats brain cortex increased expression of markers of the functional activity of cells: Ki67 and serotonin (1,7-fold and 2,2-fold, correspondingly) as compared to control. Thus, EDR possesses pronounced neuroprotective properties.

Adding peptide AEDG to pinealocyte cultures resulted in the stimulation of the synthesis of arylalkylamine – N-acetyltransferase (AANAT) enzyme and transcription factor pCREB, which are involved in the synthesis of melatonin from serotonin. Furthermore, under the effect of peptide AEDG the content of melatonin increased in the culture medium.

Adding peptides AEDG and KE to embryonic retinal cell cultures contributed to the induction of differentiation of various types of neurons in the retina (activation of Brn3, Pax6, Prox1, Vsx1 proteins expression) and pigment epithelium (activation of transthyretin synthesis). Adding extracted peptides of the retina to polypotential cell culture of Xenopus laevis early gastrula ectoderm led to the emergence of retinal and pigment epithelium cells. Adding of other small peptides to pluripotent cells of ectoderm in the same experimental model resulted in emergence of different tissues (nervous, liver, etc.).

The peptide AEDR proved to reinforce expression of cyto- and karyoskeleton proteins in cell cultures of embryonic fibroblasts. The peptide increased expression of cytoskeletal proteins (such as actin, tubulin and vimentin) 2-5-fold and nuclear proteins (lamin A, lamin C) 2-3-fold. Thus, mechanism of action of this peptide is based on its ability to activate synthesis of proteins in cyto- and karyoskeleton and thereby enhance cell proliferation and reduces apoptosis.

These experiments showed that peptides can induce differentiation and proliferation, as well as suppress apoptosis of cells, depending on the structure of the substance added. The results of these studies concludes that there is a possibility of targeted induction of cell differentiation and an employment of a biological cellular reserve, of various organs and tissues. This is the fundamentals for enhancing functions and reserves of human organism, as well as increasing the human lifespan to its maximal capacity.

Vitual Laboratories PEPTIDE COMPLEXES 3 Peptides in 1 capsule

VITUAL Laboratories is one of the founding companies in the field of anti-aging technologies and peptide bio regulation. The company’s researchers from the Research and Development Department are recognized as the world’s leading scientists in the field of gerontology and geriatrics.

Vitual Laboratories Peptide Complexes:

  • Contain only natural Khavinson Peptides
  • Do not cause allergies
  • Do not contain hormones
  • Do not cause side effects or a cancellation effect
  • Soft and long-lasting effect from 6 up to 12 months
  • Can be easily combined with other supplements and medicines.

Peptide bioregulators are organic substances that can stimulate biological processes in the body and include mechanisms for independent recovery. Thanks to the discovery of the method of obtaining bioregulators, scientists were able to synthesize a new type of preparations. They can slow down the rate of ageing, prolong active longevity and reduce the risk of developmental disorders associated with age-related changes.

Thanks to their ability to influence stem cells, bioregulators can activate hidden reserves within your body and accelerate recovery even after deep disturbances.

The basis of any organism consists of proteins, that form the structure of cells responsible for the transfer of other substances and activation of biochemical reactions. The coordinated work of all organs and systems depends on the rate of protein synthesis and the main regulators of protein molecules assembly are peptides. But as we grow older the number of our own regulatory peptides decreases, that negatively affects the process of cell renewal. This is compounded by the fact that stressors deactivate some DNA sites and stop the process of reading the necessary information for protein production. This leads to deterioration of health, hormonal failure and other disorders.

You can replenish the regulatory peptide pool from the outside. Polypeptide complexes renew cells and restore the functions of the corresponding organs, that leads to the elimination of health problems, improving health and prolonging active longevity.

Peptide complex consists of many short peptides that enter the stomach and intestines, are not subject to the process of cleavage and are absorbed into the blood. Peptides get from the blood into the target organs and penetrating through the cytoplasmic membrane of cells, get into the nucleus, where they bind with Nucleosom (the structural part of the chromosome, which contains the human genome) and regulate the process during which the information contained in the gene is converted into functionally active proteins that renew cells and restore the organs work. This process is called gene expression.

The uniqueness of Khavinson’s short peptides lies in the ability to increase gene activity and activate “sleeping” stem cells, that strengthen the structure of tissues and organs. In natural conditions this phenomenon is observed in a limited number of people who are considered to be long-lived.

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Youth Gems HAND CREAM 100 ml

Peptide Cosmetic from Peptide Bioregulator Sweden

The impact of adverse environmental factors (environmental, climatic, geochronopathogenic, professional and psycho-emotional) causes the creation of free radicals in the skin cells which leads to disruption of the functions of various skin structures and, as a consequence, premature aging of the skin.

The use the in the cosmetic product composition of substances with antioxidant activity and the ability to restore impaired skin functions makes it possible to level the negative impact of the environmental stress factors on the skin and prevents its premature aging. However, the antioxidant effect alone does not solve all the problems associated with impaired functioning of the skin.

The cosmetic industry development makes researchers look for more progressive solutions aimed at improving the skin condition; in this regard, scientists have recently changed their focus on peptide bioregulators.

The YOUTH GEMS® line of cosmetics – with peptides and ginseng – is a specially developed programme for comprehensive care for the skin of the face, neck, décolleté and body. The composition of cosmetic products in the series includes unique active ingredients, such as short peptides, which have a targeted tissue-specific effect on all the basic structures of the skin, and ginseng biomass extract characterised by a strong antioxidant and anti-inflammatory effect as well as a number of other active ingredients.


Anti-aging cosmetic line with peptide complexes from Garmonia

The YOUTH GEMS® line of cosmetics – with peptides and ginseng – is a specially developed programme for comprehensive care for the skin of the face, neck, décolleté and body.

The composition of cosmetic products in the series includes unique active ingredients, such as short peptides, which have a targeted tissue-specific effect on all the basic structures of the skin, and ginseng biomass extract characterised by a strong antioxidant and anti-inflammatory effect as well as a number of other active ingredients.


History and mission of Khavinson peptides foundation

The aging mechanism is an evolutionary predetermined process. According to the UN data the number of elderly and old people constantly increases worldwide, both in absolute numbers and percentage wise too. This will inevitably lead to complication and constraints on the public health and social issues. The global aging process, in terms of evolution, makes it necessary to search for new adequate ways to increase the period of working life, slow down the processes of premature aging and prevent age-related diseases.

Recently, a very important discovery in the field of biology and medicine has been made. It has been discovered that different vital resources of the human organism can be increased by 20 – 42% in respect to the experiment. This discovery occurred thanks to a new group of peptide signalling molecules. These peptides epigenetically regulate gene expression, protein synthesis and the functions of the organs. Peptides decrease tumour incidence and increase average lifespan in experimental animal studies. Administration of peptide preparations has also shown to normalize the main functions of the human organism, as well as decrease the aging pace and mortality .

During the period 1973 – 2014 professor V. Kh. Khavinson et al. extracted over 20 complexes of physiologically active peptides from various organs , as well as 17 others synthesized from amino acids, (di-, tri-, tetrapeptides), all being covered by patents in many countries including the USA, Canada, Australia, Europe, Japan, Korea, Israel, etc.

After several decades of experimental and clinical studies, six medicinal peptide preparations were approved for medical use by Ministry of Health (analogy of USA FDA) in the USSR, Russia, and afterwards in CIS countries. They were primarily used by the military medical service. These are:

Thymalin – a preparation of the thymus, being a immunity regulator;
Epithalamin – a preparation from the pineal gland – regulator of the endocrine functions;
Cortexin – a preparation from the cerebral cortex, brain function regulator;
Prostatilen – a preparation from the prostate gland, regulator of prostate function;
Retinalamin – a preparation from the retina, partially restores functions of the retina in case of degenerative diseases
Thymogen – a dipeptide (EW), being first extracted from ‘Thymalin’, then synthesized from amino acids, regulates immunity.

All came to be known as pharmaceuticals created on the basis of Khavinson peptides technology.

Scientific evidence based on 30 years of experience of the use of peptide drugs in neurology, therapy, ophthalmology and other medical disciplines show the high effectiveness of this group of pharmacopoeial drugs. Over the past 15 years, the active scientific work of researchers, physicians and pharmacologists of the Russian Federation and the CIS countries has contributed to further introduction of peptides into a daily practice of neurologists, ophthalmologists, surgeons, neurosurgeons, therapists and physicians from other fields.

Products and biotechnologies created due to their high efficacy are currently being used in industrial and military sectors as well as in space medicine. Peptide based medications were used in the complex treatment of people who suffered during earthquakes, accidents at nuclear submarines and in Chernobyl nuclear power plant accident. Further study of the effectiveness of these bioregulators on humans has clearly shown the ability of these drugs to increase the life resource of human body and to significantly reduce mortality among patients (over a 15 years long study period).

Application of Khavinson peptides

In a randomized comparative study which lasted for 15 years, in elderly people with premature cardiovascular aging, it was found that the administration of the medicinal peptide preparation ‘Epithalamin’ slowed down the rate of aging and decreased mortality. By the end of this period 16 of 40 patients in the control group (40%) and 26 of 39 patients treated with Epithalamin (66.7%) were living. A long-term application of ‘Epithalamin’ (6 courses over a period of 3-years), also slows down the aging of the cardiovascular system, preventing an age-related increase in the physical stamina, normalizing the diurnal rhythm of melatonin synthesis, as well as carbohydrate and lipid metabolism.

Treatment efficiency was evaluated by shifts in the following parameters: CVS functional age, threshold exercise power, total cholesterol, glucose concentration after overnight fasting and 2 hour after standard glucose tolerance test, plasma melatonin concentration. Threshold execise power (in W) was evaluated by bicycle ergometry using common diagnostic criteria. Cardiovascular system FA was evaluated by the method using mathematical formulas based on the threshold exercise power and haemodynamics at the peak of threshold exercise. The degree of CVS aging was calculated as the difference between functional age and actual age. Oral glucose tolerance test with 75 g glucose was carried out as recommended by the WHO. The geroprotective effect of pineal gland peptides is also confirmed by the decreased mortality rate, shown with the Kaplan-Meier survival curves (Fig. 5).

The peptide preparations of the thymus, (‘Thymalin’, peptides EW and KE) was shown to be effective in the treatment of many diseases and conditions associated with decreased cell immunity and phagocytosis after radiotherapy and chemotherapy in cancer patients. It also had an effect in many other clinical setting such as cases of acute and chronic infectious and inflammatory diseases, overuse of antibiotics, oppression of the regeneration processes in post-traumatic and postoperative complications, obliterating diseases of arteries, chronic liver or prostate diseases, and complex treatment of certain forms of tuberculosis. Application of “Thymalin” in different clinical studies improved immune functions significantly (increased amount of T-lymphocytes, T-lymphocytes-helpers, enhanced reaction of lymphocytes blast-transformation in presence of phytoheamagglutinin and Concanavalin A were registered, as well as reinforced reaction of phagocytosis).

Peptide preparation ‘Cortexin’ is an extract from the cerebral cortex wich exerts a significant neuroprotective effect. This preparation improves memory, stimulates reparative processes and accelerates restoration of ceberal functions after stress. This preparation is also effective in the treatment of craniocerebral injury, cerebral circulatory disorders, viral and bacterial neuroinfections, encephalopathy of different genesis, acute and chronic encephalitis and encephalomyelitis. A particularly high efficiency of this peptide preparation was noted in elderly patients.

A remarkable clinical effect has been observed with the peptide ‘Retinalamin’, which is extracted from the retina of animals. This unique preparation is applied in patients with various degenerative diseases of the retina such as; diabetic retinopathy, involutional degeneration, retinitis pigmentosa and other pathologies. Of particular importance is its ability to restore electrical activity of the retina, moreover this restoration usually correlates with an improvement of visual functions (vision acuity, fields of vision, electro-physiological investigation).

Another peptide preparation which is called ‘Prostatilen’ was extracted from animal prostate gland. This preparation is effective for treatment of chronic prostatitis, adenoma and complications after prostate gland surgery, as well as in different age-related prostate dysfunctions.

It should be emphasized that Khavinson peptides selectively bind to specific DNA sites in vitro. They epigenetically regulate expression of genes, (oncogenes, telomerase gene, interleukins genes, transcription factors genes) as well as the synthesis of proteins – markers of differentiation, proliferation, apoptosis and increase the length of telomeres in somatic cells. These peptides furthermore increase the average lifespan, decrease tumour incidence in animals and decrease human mortality by maintaining endocrine, nervous and immune systems.